Which drug can result in high attenuation pulmonary consolidation on CT?
Amiodarone is an antiarrhythmic agent commonly used to treat supraventricular and ventricular arrhythmias. NSIP is the most common pulmonary manifestation of amiodarone toxicity. An additional but distinctive feature of amiodarone-related pulmonary toxicity is high attenuation pulmonary consolidation. The increased attenuation is the result of amiodarone, an iodine-containing compound, which accumulates within type II pneumocytes. Similarly, increased hepatic attenuation may also be seen due to deposition in the liver. Rarely, amiodarone can result in life-threatening ARDS.