What are the pulmonary manifestations of drug toxicity on imaging?
Pharmacologic therapies that can result in pulmonary toxicity are vast. Common culprit drugs include chemotherapeutic agents such as methotrexate, bleomycin, busulfan, and cyclophosphamide. Additional commonly used drugs such as nitrofurantoin and amiodarone have also been linked to pulmonary toxicity.
The patterns of drug toxicity are usually in the form of noncardiogenic pulmonary edema, diffuse alveolar damage, pulmonary hemorrhage, organizing pneumonia, pulmonary eosinophilic syndromes, or chronic interstitial pneumonias such as usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP). Thus, the imaging manifestations are quite varied.