Which clinical characteristics increase the risk of CRC in patients with UC and Crohn’s disease

Which clinical characteristics increase the risk of CRC in patients with UC and Crohn’s disease? 

In patients with UC and Crohn’s disease, the risk of CRC increases with:

  • • Longer duration
  • • More extensive or severe colitis (more than one-third colonic involvement)
  • • Family history of CRC
  • • Young age at onset of disease
  • • Presence of backwash ileitis
  • • Personal history of primary sclerosing cholangitis.

The presence of isolated proctitis alone does not increase the risk for CRC.

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