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What is hereditary nonpolyposis colorectal cancer syndrome (HNPCC)?
- HNPCC syndrome is an autosomal dominant disorder distinguished by the early development of CRC (average age is 44).
- The diagnostic clinical criteria used to help establish the diagnosis of HNPCC include the Amsterdam (modified) and Bethesda classification systems.
What are the endoscopic screening and surveillance guidelines for HNPCC?
- Colonoscopy should be performed every 1 to 2 years in patients at risk for HNPCC, beginning at age 20 to 25 years or 10 years younger than the age of the earliest diagnosis of cancer in the family.
- The screening interval for endoscopic surveillance changes to yearly beginning at age 40.
Do patients with ulcerative colitis (UC) and Crohn’s disease require endoscopic surveillance?
- Yes. Long-standing UC and extensive Crohn’s disease increase an individual’s risk for the development of dysplasia and CRC.