Where are immune mediated peripheral neuropathies most likely to cause initial nerve damage?
Immune mediated peripheral neuropathies are most likely to cause initial nerve damage in areas where the blood–nerve barrier is deficient (i.e., motor roots, dorsal root ganglion, and motor–nerve terminals).
The blood–nerve barrier serves to protect nerve fibers and endoneurial content from the vascular compartment.
Where this barrier is incomplete, circulating cellular and humoral immune components have access to the nerve.
