What should be considered when acute rejection of kidney transplantation is diagnosed

What should be considered when acute rejection of kidney transplantation is diagnosed?

The possibility of inadequate immunosuppression should be considered whenever acute rejection is confirmed. This inadequacy may result from noncompliance, under-dosing of maintenance immunosuppressants, drug interactions, and/or rapid withdrawal of immunosuppressants post-transplantation. A systematic approach to identify the contributing factors for acute rejection should be instituted to mitigate further graft damage and eventual graft failure.

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