What should be considered when acute rejection of kidney transplantation is diagnosed

What should be considered when acute rejection of kidney transplantation is diagnosed?

• The most important aspect to be considered when there is a diagnosis of acute rejection of kidney transplantation is the most likely possibility of inadequate immunosuppression.

How this inadequate immunosuppression happens?

This inadequate immunosuppression may be due to

1. Noncompliance
2. Under dosing of maintenance immunosuppressants
3. Drug interactions
4. Rapid withdrawal of immunosuppressants post transplantation

What is the mode of approach to handle this situation?

An appropriate systematic approach is necessary to identify the contributing factors for acute rejection

This approach needs to be instituted to mitigate further graft damage and eventual graft failure