4 Interesting Facts of Systemic mastocytosis
- Myeloproliferative neoplasm characterized by abnormal mast cell proliferation
- Like carcinoid syndrome, typically presents with cutaneous flushing, abdominal discomfort, and diarrhea
- Unlike carcinoid syndrome, may be associated with vomiting, pruritus, and anaphylactoid reactions
- Diagnosis suggested by presence of anemia, thrombocytopenia, leukocytosis, and elevated serum tryptase; confirmed histologically by the presence of dense infiltrates of mast cells in bone marrow or other tissue
