Systemic mastocytosis

4 Interesting Facts of Systemic mastocytosis

  1. Myeloproliferative neoplasm characterized by abnormal mast cell proliferation
  2. Like carcinoid syndrome, typically presents with cutaneous flushing, abdominal discomfort, and diarrhea
  3. Unlike carcinoid syndrome, may be associated with vomiting, pruritus, and anaphylactoid reactions
  4. Diagnosis suggested by presence of anemia, thrombocytopenia, leukocytosis, and elevated serum tryptase; confirmed histologically by the presence of dense infiltrates of mast cells in bone marrow or other tissue
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