What is systemic AL amyloidosis?
Systemic AL amyloidosis, formerly called primary amyloidosis, is due to protein deposition derived from immunoglobulin light-chain fragments. AL amyloid appears to represent a spectrum of disease. At one end, the source of light chains is a malignant clone of plasma cells (myeloma-associated). At the other extreme, light chains are derived from a small, nonproliferative plasma cell population (immunocyte dyscrasia).