Cause of Systemic Sclerosis

What is the cause of Systemic Sclerosis?

Unknown.

The etiology of Systemic Sclerosis may involve a complex interplay among a genetically-susceptible host, gender related factors, and external triggers.

Pathophysiological mechanisms that may play a role in disease development include endothelial disruption, platelet activation, fibroblast proliferation, fetal michrochimerism, and increased transforming growth factor-β.

Some environmental factors, particularly silica dust, have been associated with an increased risk of Systemic Sclerosis.

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