SLICC ACR damage index

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What disease activity indices are used in SLE? What is the SLICC/ACR damage index?

In lupus, disease burden can be measured by disease activity or damage. The disease activity measures give an assessment of the degree of active inflammation, whereas the damage scores give an idea of the downstream effects of the disease or therapies. These are not routinely used in clinical practice. There are many types of disease activity scoring systems.

Systemic Lupus Erythematosus Disease Activity and Damage Scores.

MeasureExampleUse
Disease activitySLEDAI
SLEDAI-2K
SELENA-SLEDAI
SRI
LLDAS
BILAG/BICLA
Mostly used for studies to enroll appropriate patients or assess for change in activity with an intervention
Damage scoresSLICC
BILD (patient reported measure)
Used to look for damage from the longstanding burden of disease for example:
Cardiovascular disease
Osteoporosis from steroids
Diabetes from steroids
Cancer

BILAG, British Isles Lupus Assessment Group; BICLA, BILAG-based Composite Lupus Assessment; BILD, brief index of lupus damage; LLDAS, Lupus Low Disease Activity State; SELENA, Safety of Estrogens in Lupus Erythematosus National Assessment trial; SLEDAI, systemic lupus erythematosus disease activity index; SLICC, Systemic Lupus International Collaborating Clinics; SRI , Systemic Lupus Erythematosus Responder Index.

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