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What disease activity indices are used in SLE? What is the SLICC/ACR damage index?
In lupus, disease burden can be measured by disease activity or damage. The disease activity measures give an assessment of the degree of active inflammation, whereas the damage scores give an idea of the downstream effects of the disease or therapies. These are not routinely used in clinical practice. There are many types of disease activity scoring systems.
Systemic Lupus Erythematosus Disease Activity and Damage Scores.
| Measure | Example | Use |
|---|---|---|
| Disease activity | SLEDAI SLEDAI-2K SELENA-SLEDAI SRI LLDAS BILAG/BICLA | Mostly used for studies to enroll appropriate patients or assess for change in activity with an intervention |
| Damage scores | SLICC BILD (patient reported measure) | Used to look for damage from the longstanding burden of disease for example: Cardiovascular disease Osteoporosis from steroids Diabetes from steroids Cancer |
BILAG, British Isles Lupus Assessment Group; BICLA, BILAG-based Composite Lupus Assessment; BILD, brief index of lupus damage; LLDAS, Lupus Low Disease Activity State; SELENA, Safety of Estrogens in Lupus Erythematosus National Assessment trial; SLEDAI, systemic lupus erythematosus disease activity index; SLICC, Systemic Lupus International Collaborating Clinics; SRI , Systemic Lupus Erythematosus Responder Index.
