Risk of cancer in Sjogrens Syndrome

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Risk of cancer in Sjogrens Syndrome

What is the risk of cancer in patients with Sjogrens Syndrome?

There is a 5- to 44-fold greater risk of developing lymphoma in SS compared with age-matched controls, with a lifetime frequency of lymphoma of 5% to 10%. Lymphomas are usually non-Hodgkin’s B-cell lymphomas (NHL) and occur at a median of 8 years following a diagnosis of SS. Extranodal marginal zone B-cell lymphoma (also known as mucosa-associated lymphoid tissue) is the predominant subtype of NHL seen in SS, but transformation to diffuse large B-cell lymphoma can occur.

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