Manifestations of colchicine toxicity

different manifestations of colchicine toxicity and identify patients most at risk

Risk factors for toxicity include: old age, renal impairment, hepatic impairment, chronic use, and concomitant interacting medications. Most adverse effects are related to dose and duration.

  • • Common: gastrointestinal (GI) effects (nausea, vomiting, & especially diarrhea) can occur even at recommended doses.
  • • Acute toxicity: renal failure, circulatory collapse, marrow failure, rhabdomyolysis, and respiratory failure.
  • • Chronic toxicity: most common in elderly, renal insufficiency, and interacting medications. Bone marrow suppression (thrombocytopenia, leukopenia), neuromyopathy (elevated creatinine kinase, proximal weakness, peripheral neuropathy, lysosomal vacuoles on biopsy).
  • • Rare (<1%) but notable effects: alopecia, azoospermia, oligospermia, amenorrhea, dysgeusia, central nervous system dysfunction, malabsorption syndrome (especially of vitamin B12), hemorrhagic gastritis.
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856