What is the natural history of Membranoproliferative glomerulonephritis?
Although spontaneous remission has been described in children and adolescents with Membranoproliferative glomerulonephritis, nearly 50% progress to ESKD over 10 to 15 years.
Similar outcomes are found in adults, with 50% progressing to ESKD within 5 years and 64% after 10 years of follow-up. Indicators of poor outcome include
• Elevated serum creatinine at presentation
• Nephrotic-range proteinuria
• Severe hypertension
• Crescents in more than 50% of glomeruli
• Diffuse interstitial fibrosis and tubular atrophy
• A reduced calculated GFR after 1 year of treatment
• Primary versus secondary forms of Membranoproliferative glomerulonephritis
• Type II Membranoproliferative glomerulonephritis compared as opposed to types I and III
