Are there extrarenal manifestations of Membranoproliferative glomerulonephritis?
Patients with primary Membranoproliferative glomerulonephritis generally have primarily kidney manifestations.
However, in nearly 25% of cases, patients with type II disease, which is more common in children, manifest partial lipodystrophy (gradual loss of subcutaneous fat tissue in the face and upper body).
There may be other associated findings in patients with Membranoproliferative glomerulonephritis, such as macular degeneration and mild visual field and color defects.
Retinal angiography demonstrates the presence of choroidal neovascularization.
Patients with secondary Membranoproliferative glomerulonephritis may have extrarenal abnormalities related to the underlying disease.
For example, patients with Membranoproliferative glomerulonephritis in association with cryoglobulinemia may have ulcerative skin lesions, Raynaud phenomenon, peripheral neuropathy, hepatomegaly, and signs of cirrhosis.
