15% of DMSO is broken down to MSM. MSM does not cause oyster-garlic smell. MSM is an organic sulfur compound that may contribute sulfur to the formation of connective tissue. Additionally, animal studies suggest that it may be antiinflammatory, but there are no controlled scientific data to support its use. MSM has become popular since the actor James Coburn said that it works for his RA. Usual dose is 1000 to 3000 mg twice a day.