Methylsulfonylmethane MSM

What is Methylsulfonylmethane MSM

Methylsulfonylmethane MSM is a naturally occurring, organic sulfur-containing compound.

Synonyms for MSM include methyl sulfone, and dimethyl sulfone (DMSO2). Methylsulfonylmethane is derived from dimethylsulfide (DMS), which is a result of oceanic phytoplankton production.

When DMS oxidizes photochemically, dimethyl sulfoxide (DMSO) and MSM are produced. MSM contains roughly 34% elemental sulfur, and because sulfur bonds are essential structural features in all connective tissues, methylsulfonylmethane,

MSM has been claimed to have the potential to benefit people with muscle and joint-cartilage conditions.

MSM is most often promoted as a dietary supplement for the treatment of osteoarthritis (OA).

Most published clinical studies of MSM for OA have suffered from methodological defects but have reported small improvements in pain and physical function scores; these improvements are thought to be unlikely to be clinically significant for patients.

Topical MSM products are also marketed for osteoarthritis; however, it is unknown if MSM is absorbed locally or systemically, and no published human data suggest the efficacy of topical MSM for any use.

Dietary supplementation with MSM remains of interest for sports medicine applications; it is postulated that MSM may attenuate oxidative muscle stress (e.g., myalgia, muscle inflammation) following high-intensity, long-duration exercise (e.g., marathon running), but studies are not sufficient to definitively determine efficacy.

Oral MSM has also been studied for relief of seasonal allergic rhinitis; data are very preliminary but suggest improvements in nasal symptoms with daily use.

MSM is naturally found in small quantities in some grains, fruits, vegetables, tea, milk, and coffee, but has no necessary nutritive value.

In the U.S., methylsulfonylmethane is sold as a non-prescription oral dietary supplement and as a topical product. MSM is generally recognized as safe or “GRAS” per the FDA. However, MSM is not regulated as a drug and, therefore, is not intended to treat, diagnose, mitigate, prevent, or cure diseases.


  • allergic rhinitis
  • osteoarthritis
  • seasonal allergies

For the treatment of osteoarthritis

Side Effects

  1. constipation
  2. diarrhea
  3. fatigue
  4. headache
  5. insomnia

Monitoring Parameters

  • laboratory monitoring not necessary


  • anticoagulant therapy
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  • breast-feeding
  • children
  • coagulopathy
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  • intracranial bleeding
  • pregnancy
  • retinal bleeding
  • retroperitoneal bleeding
  • vitamin K deficiency


  • Acetaminophen; Aspirin, ASA; Caffeine
  • Anticoagulants
  • Antithrombin III
  • Apixaban
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  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Betrixaban
  • Bivalirudin
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Desirudin
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  • Enoxaparin
  • Ethanol
  • Fondaparinux
  • Ginger, Zingiber officinale
  • Ginkgo, Ginkgo biloba
  • Ginseng, Panax ginseng
  • Green Tea
  • Heparin
  • Lepirudin
  • Nonsteroidal antiinflammatory drugs
  • Pentosan
  • Platelet Inhibitors
  • Rivaroxaban
  • Thrombolytic Agents
  • Tinzaparin
  • Warfarin

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