Medical Conditions Associated with a Positive ANA
| Condition | % ANA-positive |
|---|---|
| Systemic lupus erythematosus | 99–100 |
| Drug-induced lupus | 100 |
| Mixed connective tissue disease | 100 |
| Autoimmune liver disease (hepatitis, cholangitis) | 100 |
| Systemic sclerosis (limited and diffuse subsets) | 95 |
| Oligoarticular juvenile idiopathic arthritis (uveitis) | 70–80 |
| Polymyositis/dermatomyositis | 40–80 |
| Primary Sjögren’s syndrome | 40–80 |
| Antiphospholipid antibody syndrome | 40–50 |
| Rheumatoid arthritis | 30–50 |
| Autoimmune thyroid disease (Hashimoto’s, Graves’) | 30–50 |
| Primary pulmonary hypertension | 40 |
| Multiple sclerosis | 25 |
| Neoplasia (especially lymphoma) | 15–25 |
| Chronic infections (subacute bacterial endocarditis, tuberculosis, mononucleosis) | Varies |
ANA, antinuclear antibody.
