Medical Conditions Associated with a Positive ANA

Medical Conditions Associated with a Positive ANA

Condition% ANA-positive
Systemic lupus erythematosus99–100
Drug-induced lupus100
Mixed connective tissue disease100
Autoimmune liver disease (hepatitis, cholangitis)100
Systemic sclerosis (limited and diffuse subsets)95
Oligoarticular juvenile idiopathic arthritis (uveitis)70–80
Primary Sjögren’s syndrome40–80
Antiphospholipid antibody syndrome40–50
Rheumatoid arthritis30–50
Autoimmune thyroid disease (Hashimoto’s, Graves’)30–50
Primary pulmonary hypertension40
Multiple sclerosis25
Neoplasia (especially lymphoma)15–25
Chronic infections (subacute bacterial endocarditis, tuberculosis, mononucleosis)Varies

ANA, antinuclear antibody.


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