ANA Pattern and Associated Rheumatic Diseases

ANA Pattern and Associated Rheumatic Diseases

Homogenous (diffuse)
• DNA-histone (nucleosome)SLE, drug-induced LE, other diseases
• Mi-2Dermatomyositis (15%–20%)
Rim (peripheral)
• dsDNASLE
Speckled
• SS-A (Ro)SLE, SCLE, primary Sjögren’s, systemic sclerosis, other diseases
• SS-B (La)SLE, primary Sjögren’s, SCLE
• RNPMCTD, systemic sclerosis, SLE
• SmSLE
• KuSLE, polymyositis/systemic sclerosis overlap
Nucleolar
• Topoisomerase I (Scl-70) aSystemic sclerosis (diffuse type) (20%–30%)
• RNAP III aSystemic sclerosis (diffuse type) (4%–20%)
• Fibrillarin (U3-RNP)Systemic sclerosis (diffuse type) (8%)
• TH/TOSystemic sclerosis (limited type) (5%)
• PM- Scl (PM-1)Polymyositis overlap (1%)
Centromere (kinetochore)
• CENPLimited scleroderma

CENP, centromere protein; LE, lupus erythematosus; MCTD, mixed connective tissue disease; RNAP, RNA polymerase; RNP, ribonuclear protein; SCLE, subacute cutaneous lupus erythematosus; SLE, systemic lupus erythematosus; SS-A, Sjögren’s syndrome-related antigen A.

a Scl-70 & RNAP III have also been associated with a speckled pattern on indirect immunofluorescence.

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