ANA Pattern and Associated Rheumatic Diseases
|• DNA-histone (nucleosome)||SLE, drug-induced LE, other diseases|
|• Mi-2||Dermatomyositis (15%–20%)|
|• SS-A (Ro)||SLE, SCLE, primary Sjögren’s, systemic sclerosis, other diseases|
|• SS-B (La)||SLE, primary Sjögren’s, SCLE|
|• RNP||MCTD, systemic sclerosis, SLE|
|• Ku||SLE, polymyositis/systemic sclerosis overlap|
|• Topoisomerase I (Scl-70) a||Systemic sclerosis (diffuse type) (20%–30%)|
|• RNAP III a||Systemic sclerosis (diffuse type) (4%–20%)|
|• Fibrillarin (U3-RNP)||Systemic sclerosis (diffuse type) (8%)|
|• TH/TO||Systemic sclerosis (limited type) (5%)|
|• PM- Scl (PM-1)||Polymyositis overlap (1%)|
|• CENP||Limited scleroderma|
CENP, centromere protein; LE, lupus erythematosus; MCTD, mixed connective tissue disease; RNAP, RNA polymerase; RNP, ribonuclear protein; SCLE, subacute cutaneous lupus erythematosus; SLE, systemic lupus erythematosus; SS-A, Sjögren’s syndrome-related antigen A.
a Scl-70 & RNAP III have also been associated with a speckled pattern on indirect immunofluorescence.