Is immunoglobulin a nephropathy associated with any other conditions?
Yes. Although immunoglobulin a nephropathy is most commonly a primary (idiopathic) disorder, there are some well-established associations.
The most common are
• Liver cirrhosis (both alcohol- and virus-induced)
• Celiac disease
• HIV infection
• Inflammatory bowel disease
• Some rheumatic conditions
IgAN has also been described in association with
• Minimal change disease (MCD)
• Membranous nephropathy
• Antineutrophil cytoplasmic antibody-positive vasculitis
There is increased recognition of IgA deposition with Staphylococcus -related glomerulonephritis (GN). However, unlike primary IgAN, the presence of the active infection and typical large subepithelial deposits (humps) on microscopy can help distinguish between these two entities.
