Is there a genetic contribution to Membranoproliferative glomerulonephritis?
Abnormal complement activation in Membranoproliferative glomerulonephritis can occur as a consequence of genetic mutations with reduced endogenous inhibitors of the alternate pathway, such as factor H, or because of the presence of a circulating autoantibody that stabilizes C3 convertase.
Membranoproliferative glomerulonephritis occurs in patients who carry homozygous mutations in factor H.
Other genetic causes of Membranoproliferative glomerulonephritis include isolated C4 deficiency.
