Is pernicious anemia at risk for gastric cancer

Are patients with pernicious anemia at an increased risk for gastric cancer? Is endoscopic screening or surveillance required? 

Yes. Individuals with pernicious anemia have an estimated two- to threefold increased risk of developing gastric cancer. The risk for developing gastric cancer in patients with pernicious anemia is highest within the first year of diagnosis, so a single endoscopy should be considered to identify prevalent neoplasia. There is insufficient data to support subsequent endoscopic surveillance.

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