Is digital mammography better than film screen mammography in detecting breast cancer?
The largest prospective multicenter trial comparing digital mammography with film screen mammography is the Digital Mammographic Imaging Screening Trial (DMIST) sponsored by ACRIN. The study recruited more than 49,000 women. Overall, in the general population, the study showed that the accuracy of digital mammography was similar to film screen mammography. However, digital mammography was superior to film screen mammography in certain subpopulations, including women younger than age 50 years, women with heterogeneously or extremely dense breasts, and premenopausal or perimenopausal women.