Important adhesins in intracellular matrices

Important adhesins in intracellular matrices

What are the important adhesins (cell-binding glycoproteins) that can be present in intracellular matrices and basement membranes

  • Fibronectin—connective and many other tissues.
  • Laminin—basement membrane.
  • Chondroadherin—cartilage.
  • Osteoadherin (osteomodulin)—bone.

These glycoproteins have specific adhesive and other important properties. They bind cells by attaching to integrins on cells. Some have the classical arginine–glycine–aspartic acid cell-binding sequence. In addition, there are cadherins that are transmembrane polypeptides that mediate cell–cell adhesion and recognition.

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