How prevalent is Axial Spondyloarthritis among HLA B27 positive

How prevalent is Axial Spondyloarthritis among HLA B27 positive individuals, among HLA-B27-positive individuals who has a relative with AS, and among different ethnic groups?

The overall prevalence of AS in the general US population is 0.30% to 0.50%. Only 2% to 6% of HLA-B27-positive individuals develop AS during their lifetime. However, among those HLA-B27-positive individuals with an affected first-degree relative, the rate rises to 15% to 20%. AS is associated with HLA-B27 in all ethnic groups, which explains why the prevalence of AS corresponds to the prevalence of HLA-B27 in a particular ethnic group. Since the prevalence of HLA-B27 in northern latitudes is high (up to 15% of Scandinavians) and low (<1% of African blacks and Asians) in ethnic populations near the equator, there is an apparent decrease in the prevalence of AS going from the North Pole to the equator.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856