How is dyspepsia treated?
Treatment of dyspepsia depends on the underlying cause. If Hp is present, treatment is directed against the pathogenic organism. Common drug regimens include 10- to 14-day courses of triple (proton pump inhibitor [PPI], clarithromycin and amoxicillin) or quadruple therapy (PPI, bismuth subsalicylate, metronidazole and tetracycline). If there is no evidence of concurrent PUD, the likelihood of symptom resolution is 10% to 15%. If ulcers are identified, treatment includes a course of antisecretory drug therapy with either a PPI (preferred) or a second-generation antihistamine. These medications alleviate symptoms and promote mucosal healing. If no abnormalities are identified, and the patient is diagnosed with functional dyspepsia, standard therapies include PPIs, pro-kinetic agents, and anti-depressants.