How does hypercalcemia occur during immobilization

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How does hypercalcemia occur during immobilization?

Immobilization regularly leads to accelerated bone resorption and hypercalcemia primarily in individuals with high rates of bone turnover (e.g., adolescents on bed rest or patients with Paget disease).

Hypercalcemia is preceded by hypercalciuria, which may lead to kidney stones.

Hypercalcemia promptly reverses with the resumption of normal weight bearing.

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