How does hand foot syndrome present in a patient with Sickle Cell Disease?
Hand–foot syndrome or sickle cell dactylitis is a problem typically seen in infants or children with SCD. Children present with acute pain and swelling diffusely in the fingers or toes, usually as a first manifestation of SCD. Fever and leukocytosis may accompany the dactylitis. The etiology is thought to be local bone marrow ischemia. Subperiosteal new bone formation may be seen on radiographs of the metacarpal or metatarsal bones 2 weeks after the acute episode. Symptoms generally spontaneously subside in a few weeks.
