GI Manifestations of Common Endocrine Syndromes

GI manifestations of common endocrine syndromes and neoplastic disorders

Autoimmune polyglandular syndromes and multiple endocrine neoplasias affect various endocrine systems, but they also affect the GI tract. The below table provides a summary.

GI Manifestations of Common Endocrine Syndromes

GI ManifestationsNon-GI Manifestations
APS Type 1Oral candidiasis, pernicious anemia, celiac diseaseHypoparathyroidism
Adrenal insufficiency
Hypogonadism
Autoimmune thyroid disease
Alopecia
APS Type 2Type 1 diabetes (pancreatic failure)Autoimmune thyroid disease
Adrenal insufficiency
MEN Type 1Pancreatic tumors (e.g., insulinoma, gastrinoma)Hyperparathyroidism
Pituitary tumor
MEN Type 2AHirschsprung’s disease (colonic obstruction and megacolon)Medullary thyroid cancer
Pheochromocytoma
Hyperparathyroidism
MEN Type 2BMucosal neuromas affecting tongue and intestinesMedullary thyroid cancer
Pheochromocytoma

APS, Autoimmune polyglandular syndrome; GI, gastrointestinal; MEN, multiple endocrine neoplasia.

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