Generalized epilepsy with febrile seizures plus GEFS+
GEFS+ is an epilepsy syndrome with a highly variable phenotype.
Within a single family some affected members may have febrile seizures alone, some may have febrile seizures and afebrile seizures, and others may have only afebrile seizures.
The understanding of GEFS+ has been significantly advanced by the discovery of several associated genes including SCN1A , SCN1B , and GABARG2 .
Given that these genes encode ion channel or ionotropic receptor subunits, GEFS+ is presently considered a “channelopathy.”