DIRA and DITRA syndromes

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What are deficiency of the IL 1 receptor antagonist (DIRA) and deficiency of IL-36 receptor antagonist (DITRA) syndromes?

DIRA results from a mutation to the IL-1RN gene, leading to loss of IL-1ra secretion and unchecked IL-1 signaling. DITRA results from a mutation to the IL-36RN gene, leading to unchecked IL-36 signaling. 

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