Contraindications of 90 Y radioembolization
• Uncorrectable coagulopathy
• Severe anaphylactic or anaphylactoid contrast reaction
• Severe liver or renal dysfunction
• Lung or gastrointestinal (GI) shunts that cannot be corrected
• Untreated varices at high risk of bleeding
• Bilirubin greater than 2 mg/dL in the absence of a reversible cause
• Greater than 70% tumor replacement of liver unless synthetic function (prothrombin time and albumin) is maintained
• Prior radiation therapy to the liver or upper abdomen that included a significant volume of the liver
• Systemic chemotherapy agents in the preceding 4 weeks not known to be used safely concurrently with radioembolization
• Granulocyte count less than 1.5 × 10 9 /L
