Common skin manifestations in Mixed cryoglobulinemia
What are the common cutaneous manifestations in Mixed cryoglobulinemia?
Palpable purpura is the most common manifestation, being seen in up to 100% of patients during the course of disease. Urticarial vasculitis can also occur. Lesions typically affect the lower extremities, but can involve the trunk and upper extremities. They usually resolve spontaneously, but tend to be recurrent. Because cryoglobulinemic vasculitis can involve both small and medium vessels, more severe cutaneous lesions such as large skin ulcers occurring above the malleoli are not uncommon. Digital necrosis, bullae, and livedo racemosa may also be seen.
