Common rheumatologic syndromes are associated with hypothyroidism

What other common rheumatologic syndromes are associated with hypothyroidism?

Think of TRAP:

  • T—T unnel (carpal) syndrome (15% of hypothyroid patients; secondary to accumulation of glycosaminoglycans and subsequent edema within the carpal tunnel).
  • R—R aynaud’s phenomenon.
  • A—A ching muscles with findings indistinguishable from those of fibromyalgia (up to 30% of hypothyroid patients).
  • P—P roximal muscle weakness and stiffness with an elevated CK. Thyroid-stimulating hormone (TSH) always very high (>20) and thyroxine (T4) low.

Although chondrocalcinosis has also been ascribed to hypothyroidism, it probably does not occur more commonly than in age-matched controls.

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