Common pathogens causing bacterial meningitis by population group

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Common pathogens causing bacterial meningitis by population group

Name the common pathogens causing bacterial meningitis by population group, and indicate the typical empiric therapy for these bacterial pathogens.

Population GroupCommon PathogensEmpiric Therapy
NewbornsGram negative: Escherichia coli Klebsiella Enterobacter Proteus group B streptococci: Streptococcus agalactiaeCefotaxime + Ampicillin
Infants and childrenNeisseria meningitidis Streptococcus pneumoniae Hemophilus influenzaeCeftriaxone or cefotaxime plus vancomycin
Healthy, immunocompetentN. meningitidis S. pneumoniae Listeria monocytogenesThird/fourth-generation cephalosporin plus ampicillin plus vancomycin
Nosocomial/postneurosurgicalGram-negative Enterobacteriaceae, Pseudomonas aeruginosa , staphylococciMeropenem plus vancomycin
VentriculitisStaphylococcus epidermidis Staphylococcus aureus , gram-negative Enterobacteriaceae, P. aeruginosaMeropenem plus vancomycin
ElderlyL. monocytogenes , gram-negative Enterobacteriaceae, P. aeruginosa , pneumococciThird/fourth-generation cephalosporin plus ampicillin plus vancomycin

Sources

Roos KL (Editor): Principles of Neurologic Infectious Diseases: Principles and Practice . New York, McGraw-Hill, 2004.

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