Cells of origin and the immunohistochemical profile of Paget disease

What are the cells of origin and the immunohistochemical profile of Paget disease? 

  • The Paget cells (intraepithelial large cells with pale pink cytoplasm and large nuclei) are believed to be of apocrine lineage and show immunoreactivity with low-molecular-weight keratins Cam 5.2, CK7, and carcinoembryonic antigen.
  • Mucin stain may be positive.
  • The differential diagnosis includes pagetoid spread from adjacent CRC and melanoma in-situ. The immunoprofile helps.
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