Perianal Paget disease

What is perianal Paget disease

Perianal (extramammary) Paget disease is characterized by a scaly, inflamed dermis resembling eczema. Biopsy reveals typical Paget cells with round, pale, vacuolated, mucin-positive cytoplasm with an eccentric reticular nucleus. It is often a chronic condition, but underlying carcinoma must be ruled out as invasive anorectal cancer may be associated with Paget disease.


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