Autoantibodies present in HCV infection

Autoantibodies present in HCV infection

Patients with HCV may produce autoantibodies including ANA, anticardiolipin antibodies, antithyroid antibodies, anti-smooth muscle antibodies, anti-liver-kidney microsomal antibody 1, RF, and celiac disease autoantibodies as a consequence of nonspecific B-cell activation. In HCV-related arthritis, the frequency of RF is as high as 80%, whereas anticyclic citrullinated peptide (anti-CCP) antibodies are uncommon and should prompt consideration of a diagnosis of concurrent RA.


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