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What is Zileuton
Zileuton is an oral leukotriene modifier, specifically an inhibitor of leukotriene synthesis.
Zileuton inhibits the first enzyme in the lipoxygenase pathway, 5-lipoxygenase, and thereby limits the formation of potent leukotrienes (LTB4, LTC4, LTD4, and LTE4) which are implicated in the complicated inflammatory response that occurs in certain disease states.
Zileuton is indicated for the prophylaxis and chronic maintenance treatment of asthma in adult and pediatric patients 12 years of age and older.
Brand Name
- Zyflo
- Zyflo CR
Indications & Dosage
- aspirin-induced asthma
- asthma
- exercise-induced bronchospasm prophylaxis
For the prophylaxis and chronic maintenance treatment of asthma
Side Effects
- abdominal pain
- agitation
- anxiety
- arthralgia
- asthenia
- chest pain (unspecified)
- chills
- conjunctivitis
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- elevated hepatic enzymes
- fatigue
- fever
- flatulence
- hallucinations
- headache
- hepatitis
- hyperbilirubinemia
- hypertonia
- infection
- insomnia
- irritability
- jaundice
- leukopenia
- lymphadenopathy
- malaise
- myalgia
- nausea
- paresthesias
- pruritus
- rash
- restlessness
- seizures
- sinusitis
- suicidal ideation
- tremor
- vaginitis
- vomiting
Monitoring Parameters
- LFTs
Contraindications
- acute bronchospasm
- alcoholism
- behavioral changes
- breast-feeding
- children
- geriatric
- hepatic disease
- hepatitis
- hepatotoxicity
- infants
- jaundice
- neonates
- pregnancy
- psychiatric event
- status asthmaticus
- suicidal ideation
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Alfentanil
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atazanavir
- Atazanavir; Cobicistat
- Azelastine; Fluticasone
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendamustine
- Bepridil
- Betamethasone
- Boceprevir
- Bosentan
- Bromocriptine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buspirone
- Caffeine
- Caffeine; Ergotamine
- Carbamazepine
- Ceritinib
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Ciclesonide
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Crizotinib
- Cyclosporine
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazepam
- Dihydroergotamine
- Diltiazem
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxercalciferol
- Dronedarone
- Duloxetine
- Dutasteride; Tamsulosin
- Elbasvir; Grazoprevir
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Felodipine
- Ergoloid Mesylates
- Ergonovine
- Ergotamine
- Estazolam
- Ezetimibe; Simvastatin
- Felodipine
- Fludrocortisone
- Flunisolide
- Fluoxetine; Olanzapine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol; Mometasone
- Fosamprenavir
- Green Tea
- Halofantrine
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocortisone
- Idelalisib
- Indinavir
- Isavuconazonium
- Isradipine
- Levomethadyl
- Lidocaine
- Lomitapide
- Lopinavir; Ritonavir
- Lovastatin
- Lovastatin; Niacin
- Mefloquine
- Melatonin
- Methylergonovine
- Methylprednisolone
- Methysergide
- Mexiletine
- Midazolam
- Mitotane
- Mometasone
- Nelfinavir
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Obeticholic Acid
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Oxybutynin
- Paricalcitol
- Pazopanib
- Peginterferon Alfa-2b
- Pimozide
- Pirfenidone
- Pomalidomide
- Posaconazole
- Prednisolone
- Prednisone
- Propafenone
- Propranolol
- Protease inhibitors
- Quazepam
- Quinidine
- Ramelteon
- Rasagiline
- Riluzole
- Ritonavir
- Rofecoxib
- Ropinirole
- Ropivacaine
- Saquinavir
- Sildenafil
- Silodosin
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- St. John’s Wort, Hypericum perforatum
- Tacrine
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Telaprevir
- Telotristat Ethyl
- Terbinafine
- Terfenadine
- Theophylline, Aminophylline
- Thiabendazole
- Tipranavir
- Tizanidine
- Trandolapril; Verapamil
- Triamcinolone
- Triazolam
- Vemurafenib
- Verapamil
- Voriconazole
- Warfarin
- Zonisamide
