Zafirlukast

What is Zafirlukast

Zafirlukast is an oral leukotriene receptor antagonist for the treatment of asthma. Leukotriene receptor antagonists primarily help to control the inflammatory process of asthma, thus helping to prevent asthma symptoms.

Zafirlukast has been effective in controlling persistent asthma symptoms in adults and children >= 5 years of age as monotherapy or in combination with inhaled corticosteroids or beta-agonists.

Consistent improvements in lung function (i.e., FEV₁) and decreased use of inhaled beta-2 agonists for rescue therapy are seen with the use of zafirlukast in the treatment of mild-to-moderate asthma.

Leukotriene antagonists are considered an alternate, but not preferred, treatment to the use of inhaled corticosteroids (ICSs) for mild persistent asthma (step 2 care) according to the 2007 guidelines of the Expert Panel of the National Asthma Education and Prevention Program.

Brand Name

Accolate

Indications & Dosage

• allergic rhinitis
• asthma
• exercise-induced bronchospasm prophylaxis

For the chronic treatment and prevention of the symptoms of asthma, either as monotherapy or as add-on therapy in patients whose persistent mild-moderate asthma is inadequately controlled with inhaled corticosteroids.

Side Effects

1. abdominal pain
2. agitation
3. agranulocytosis
4. angioedema
5. anxiety
6. arthralgia
7. asthenia
8. back pain
9. chest pain (unspecified)
10. Churg-Strauss syndrome
11. clastogenesis
12. depression
13. diarrhea
14. dizziness
15. dyspepsia
16. dyspnea
17. ecchymosis
18. elevated hepatic enzymes
19. eosinophilia
20. eosinophilic pneumonia
21. fatigue
22. fever
23. hallucinations
24. headache
25. hepatic failure
26. hepatitis
27. hyperbilirubinemia
28. infection
29. insomnia
30. irritability
31. jaundice
32. lethargy
33. malaise
34. myalgia
35. nausea
36. peripheral neuropathy
37. pharyngitis
38. pruritus
39. rash
40. restlessness
41. seizures
42. sinusitis
43. suicidal ideation
44. tremor
45. urticaria
46. vasculitis
47. vesicular rash
48. vomiting
49. weakness

Monitoring Parameters

• LFTs

Contraindications

• acute bronchospasm
• breast-feeding
• children
• corticosteroid withdrawal
• depression
• females
• geriatric
• hepatic disease
• hepatic encephalopathy
• hepatitis
• infants
• jaundice
• neonates
• pregnancy
• status asthmaticus
• suicidal ideation
• vasculitis

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