What medications have uricosuric effect even if not prescribed for this reason?
- Losartan: modest uricosuric effect, plateaus at 50 mg daily.
- Fenofibrate: may induce ∼20% decrease in serum uric acid.
- Atorvastatin (note the risk of myopathy with statins + fibrates).
- High-dose (>4 g/day) salicylates.
Pearl: consider choosing medications with urate-lowering “side effect” for patients with gout and comorbid hypertension or dyslipidemia.