Vardenafil

What is Vardenafil

Vardenafil belongs to the phosphodiesterase type 5 (PDE5) inhibitors drug class, a class of drugs commonly indicated for treatment of erectile dysfunction (ED). It is a selective phosphodiesterase (PDE) type 5 inhibitor similar to sildenafil and tadalafil. This class of drugs does not inhibit prostaglandins as do some agents for treating ED (e.g., alprostadil).

Vardenafil and tadalafil are more selective for PDE5 than PDE6, which is present in the retina. This leads to less visual adverse effects such as those reported in sildenafil-treated patients.

The advantage of vardenafil may be that it achieves maximum plasma concentration sooner than sildenafil and tadalafil which may result in a faster onset of action.

In an analysis of 580 patients, erections improved in 80% of men, and the ability to complete sexual intercourse with ejaculation was increased. Efficacy in treating diabetics and radical prostectomy patients has also been demonstrated.

According to ED treatment guidelines, oral phosphodiesterase type 5 inhibitors (PDE5 inhibitor) are considered first-line therapy.

Vardenafil was approved by the FDA in August 2003 for erectile dysfunction. An orally disintegrating tablet was approved by the FDA in June 2010.

Brand Names

  • Levitra
  • Staxyn

Indications

  • erectile dysfunction (ED)

For the treatment of erectile dysfunction (ED) including ED associated with diabetes or after radical prostatectomy

Side Effects

  1. abdominal pain
  2. amnesia
  3. anaphylactoid reactions
  4. angina
  5. angioedema
  6. arthralgia
  7. asthenia
  8. back pain
  9. blurred vision
  10. chest pain (unspecified)
  11. conjunctivitis
  12. diarrhea
  13. dizziness
  14. drowsiness
  15. dysesthesia
  16. dyspepsia
  17. dysphagia
  18. dyspnea
  19. ejaculation dysfunction
  20. elevated hepatic enzymes
  21. epistaxis
  22. erythema
  23. esophagitis
  24. flushing
  25. gastritis
  26. gastroesophageal reflux
  27. headache
  28. hearing loss
  29. hyperemia
  30. hyperhidrosis
  31. hypertension
  32. hypertonia
  33. hypotension
  34. insomnia
  35. lacrimation
  36. laryngeal edema
  37. muscle cramps
  38. myalgia
  39. myocardial infarction
  40. nasal congestion
  41. nausea
  42. non-arteritic anterior ischemic optic neuropathy
  43. ocular pain
  44. orthostatic hypotension
  45. palpitations
  46. paresthesias
  47. pharyngitis
  48. photophobia
  49. photosensitivity
  50. priapism
  51. pruritus
  52. QT prolongation
  53. rash
  54. rhinitis
  55. seizures
  56. sinus tachycardia
  57. sinusitis
  58. syncope
  59. tinnitus
  60. ventricular tachycardia
  61. vertigo
  62. visual impairment
  63. vomiting
  64. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • alcoholism
  • angina
  • aortic stenosis
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • coagulopathy
  • coronary artery disease
  • diabetes mellitus
  • females
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • hearing impairment
  • heart failure
  • hepatic disease
  • hereditary fructose intolerance
  • hiatal hernia
  • human immunodeficiency virus (HIV) infection
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypotension
  • idiopathic hypertrophic subaortic stenosis
  • infants
  • leukemia
  • long QT syndrome
  • malnutrition
  • multiple myeloma
  • myocardial infarction
  • neonates
  • nitrate/nitrite therapy
  • non-arteritic anterior ischemic optic neuropathy
  • penile structural abnormality
  • peptic ulcer disease
  • phenylketonuria
  • polycythemia
  • pregnancy
  • priapism
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • retinitis pigmentosa
  • sickle cell disease
  • stroke
  • thyroid disease
  • tinnitus
  • visual disturbance

Interactions

  • Abarelix
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Alfuzosin
  • Alpha-blockers
  • Amiodarone
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amyl Nitrite
  • Anagrelide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Azithromycin
  • Bedaquiline
  • Bepridil
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Ceritinib
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloramphenicol
  • Chloroquine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Class IA Antiarrhythmics
  • Clofazimine
  • Clozapine
  • Cobicistat
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Deutetrabenazine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doxazosin
  • Dronedarone
  • Droperidol
  • Dutasteride; Tamsulosin
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Entrectinib
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Ezogabine
  • Fedratinib
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluvoxamine
  • Fosamprenavir
  • Foscarnet
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Glasdegib
  • Goserelin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Phenylephrine
  • Halofantrine
  • Halogenated Anesthetics
  • Haloperidol
  • Histrelin
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrocodone; Phenylephrine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Indinavir
  • Inotuzumab Ozogamicin
  • Isavuconazonium
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Letermovir
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levofloxacin
  • Levomethadyl
  • Lithium
  • Lofexidine
  • Lomefloxacin
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorcaserin
  • Macimorelin
  • Maprotiline
  • Mefloquine
  • Meperidine; Promethazine
  • Mesoridazine
  • Methadone
  • Metronidazole
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Moxifloxacin
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pimavanserin
  • Pimozide
  • Pitolisant
  • Posaconazole
  • Prazosin
  • Primaquine
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rilpivirine
  • Riociguat
  • Risperidone
  • Ritonavir
  • Romidepsin
  • Sapropterin
  • Saquinavir
  • Selpercatinib
  • Sertraline
  • Short-acting beta-agonists
  • Silodosin
  • Siponimod
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Sunitinib
  • Tacrolimus
  • Tadalafil
  • Tamoxifen
  • Tamsulosin
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Terazosin
  • Tetrabenazine
  • Thiethylperazine
  • Thioridazine
  • Tipranavir
  • Tolterodine
  • Toremifene
  • Trandolapril; Verapamil
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Triptorelin
  • Tucatinib
  • Vandetanib
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Voriconazole
  • Vorinostat
  • Ziprasidone
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