What is Valdecoxib
NOTE: This drug is discontinued in the US.
Valdecoxib is a selective cyclooxygenase-2 (COX-2), nonsteroidal anti-inflammatory drug (NSAID).
Valdecoxib exhibits anti-inflammatory, analgesic, and antipyretic activities but does not inhibit platelet aggregation. It is indicated for the management of dysmenorrhea, osteoarthritis, and rheumatoid arthritis.
Clinical trials have demonstrated similar efficacy and a significantly lower incidence of GI side effects for valdecoxib as compared to naproxen for symptomatic management of osteoarthritis or rheumatoid arthritis. A supplemental NDA for the treatment of migraine was filed with the FDA in April 2004. Valdecoxib was FDA-approved in November 2001.
On April 7, 2005, Pfizer announced a voluntary suspension of valdecoxib from the U.S. and European Union markets.
Although the cardiovascular risk of valdecoxib could not be differentiated from other NSAIDs, the FDA has concluded that the additional, increased risk of rare but serious skin reactions associated with valdecoxib warrants its withdrawal from the market.
Patients who are taking valdecoxib should discuss other treatment options with their physicians.
Brand Name
Bextra
Indications
- bone pain
- dental pain
- dysmenorrhea
- moderate pain
- osteoarthritis
- rheumatoid arthritis
- severe pain
For the management of signs and symptoms of osteoarthritis and rheumatoid arthritis
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- angina
- angioedema
- aseptic meningitis
- azotemia
- back pain
- cardiomyopathy
- chest pain (unspecified)
- diarrhea
- dizziness
- dyspepsia
- dysphagia
- edema
- elevated hepatic enzymes
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- flatulence
- GI bleeding
- headache
- heart failure
- hematemesis
- hyperkalemia
- hypertension
- hyponatremia
- hypotension
- melena
- myalgia
- myocardial infarction
- nausea
- odynophagia
- peptic ulcer
- peripheral edema
- phlebitis
- proteinuria
- pulmonary embolism
- pyrosis (heartburn)
- rash
- renal papillary necrosis
- sinusitis
- Stevens-Johnson syndrome
- stroke
- thrombosis
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- (drug no longer available)
- CBC
- LFTs
- serum creatinine/BUN
- stool guaiac
Contraindications
- acute bronchospasm
- alcoholism
- anemia
- angioedema
- anticoagulant therapy
- asthma
- bone marrow suppression
- breast-feeding
- cardiac disease
- cerebrovascular disease
- chemotherapy
- children
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dehydration
- diabetes mellitus
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hepatic disease
- hepatitis
- hypertension
- hypovolemia
- immunosuppression
- infants
- jaundice
- labor
- lactase deficiency
- nasal polyps
- neonates
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral edema
- peripheral vascular disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- rheumatoid arthritis
- salicylate hypersensitivity
- serious rash
- stroke
- sulfonamide hypersensitivity
- systemic lupus erythematosus (SLE)
- tobacco smoking
- urticaria
Interactions
- Abciximab
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