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What is Urofollitropin
Urofollitropin is a parenteral, human derived urinary gonadotropin formulation used in infertility treatments. The key differences in human-derived FSH (i.e., urofollitropin) and genetically engineered FSH (i.e., r-FSH) are product sources and cost.
Urofollitropin treatments are highly purified follitropins extracted from the urine of postmenopausal women. Urofollitropin contains primarily follicle stimulating hormone (FSH).
Brand Name
Bravelle
Indications
- hypogonadism
- infertility
- oligospermia
Side Effects
- abdominal pain
- acne vulgaris
- acute respiratory distress syndrome (ARDS)
- alopecia
- anaphylactoid reactions
- anasarca
- angioedema
- ascites
- chills
- constipation
- dehydration
- depression
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- ectopic pregnancy
- emotional lability
- exfoliative dermatitis
- fever
- flatulence
- gynecomastia
- headache
- hot flashes
- hypertension
- hypoalbuminemia
- hypotension
- hypovolemia
- injection site reaction
- laryngeal edema
- leukorrhea
- malaise
- mastalgia
- menstrual irregularity
- musculoskeletal pain
- nausea
- new primary malignancy
- oliguria
- ovarian enlargement
- ovarian hyperstimulation syndrome (OHSS)
- pelvic pain
- pericardial effusion
- phlebitis
- pleural effusion
- pruritus
- pulmonary edema
- pulmonary embolism
- rash
- sinusitis
- stroke
- thromboembolism
- thrombosis
- urticaria
- uterine contractions
- vaginal bleeding
- vaginal discharge
- vomiting
- weight gain
- xerosis
Monitoring Parameters
- blood pressure
- pelvic exam
- pelvic ultrasound
- pregnancy testing
- serum estradiol concentrations
- serum gonadotropin concentrations
- weight
Contraindications
- adrenal insufficiency
- ascites
- asthma
- breast-feeding
- children
- driving or operating machinery
- dysfunctional uterine bleeding
- endometriosis
- geriatric
- infertility
- obesity
- ovarian cyst
- ovarian failure
- pituitary adenoma
- polycystic ovary syndrome
- pregnancy
- testicular failure
- thromboembolic disease
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine leiomyomata
- vaginal bleeding
Interactions
There are no drug interactions associated with Urofollitropin, FSH products.
