What's on this Page
What is Typhoid Vaccine
Typhoid vaccine is available as a sterile solution containing purified Vi polysaccharide extracted from the bacterial capsule of Salmonella typhi for intramuscular use (Typhim Vi) or a live attenuated vaccine for oral use (Vivotif).
These preparations are used to promote active immunity to typhoid fever for individuals who are at risk of infection.
Routine vaccination with typhoid vaccine is not recommended in the US.
Selective vaccination is recommended for persons who travel to areas where there is a recognized risk of exposure to S. typhi, persons with intimate exposure to a documented S. typhi carrier, and persons who frequently work with S. typhi in microbiology laboratories.
Brand Names
- Typhim Vi
- Vivotif (PaxVax, Inc.)
- Vivotif Berna
Indications
- typhoid prophylaxis
For primary immunization against typhoid disease cause by Salmonella typhi (typhoid prophylaxis) in persons at risk of infection
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- arthralgia
- asthenia
- diarrhea
- dyspnea
- erythema
- fever
- glomerulonephritis
- headache
- hypotension
- injection site reaction
- lymphadenopathy
- malaise
- myalgia
- nausea
- neutropenia
- pruritus
- rash
- seizures
- serum sickness
- syncope
- tremor
- urticaria
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- agammaglobulinemia
- anticoagulant therapy
- breast-feeding
- chemotherapy
- children
- coagulopathy
- corticosteroid therapy
- diarrhea
- fever
- hemophilia
- human immunodeficiency virus (HIV) infection
- hypogammaglobulinemia
- immunosuppression
- infants
- infection
- intravenous administration
- leukemia
- lymphoma
- neonates
- neoplastic disease
- pregnancy
- radiation therapy
- severe combined immunodeficiency (SCID)
- subcutaneous administration
- thrombocytopenia
- vitamin K deficiency
- vomiting
- yeast hypersensitivity
Interactions
- Abatacept
- Adalimumab
- Aldesleukin, IL-2
- Alefacept
- Alemtuzumab
- Alkylating agents
- Alpha interferons
- Altretamine
- Anakinra
- Anthracyclines
- Antimetabolites
- Antithymocyte Globulin
- Antitumor antibiotics
- Atovaquone; Proguanil
- Axicabtagene Ciloleucel
- Azathioprine
- Baricitinib
- Basiliximab
- Belatacept
- Belimumab
- Bexarotene
- Blinatumomab
- Brodalumab
- Busulfan
- Canakinumab
- Carmustine, BCNU
- Certolizumab pegol
- Chlorambucil
- Cisplatin
- Clofarabine
- Cortisone
- Cyclophosphamide
- Cyclosporine
- Cytarabine, ARA-C
- Dacarbazine, DTIC
- Daclizumab
- Deflazacort
- Dexamethasone
- Docetaxel
- Dupilumab
- Efalizumab
- Emapalumab
- Erythromycin; Sulfisoxazole
- Estramustine
- Etanercept
- Everolimus
- Fingolimod
- Floxuridine
- Fludrocortisone
- Fluorouracil, 5-FU
- Folate analogs
- Golimumab
- Guselkumab
- Hydrocortisone
- Ifosfamide
- Imatinib
- Infliximab
- Interferon Gamma-1b
- Ixabepilone
- Ixekizumab
- Leflunomide
- Lenalidomide
- Lomustine, CCNU
- Mechlorethamine, Nitrogen Mustard
- Mefloquine
- Melphalan
- Methylprednisolone
- Mitoxantrone
- Muromonab-CD3
- Mycophenolate
- Natalizumab
- Nelarabine
- Nilotinib
- Obinutuzumab
- Ocrelizumab
- Ofatumumab
- Ozanimod
- Paclitaxel
- Penicillins
- Prednisolone
- Prednisone
- Procarbazine
- Purine analogs
- Pyrimethamine; Sulfadoxine
- Rilonacept
- Risankizumab
- Rituximab
- Rituximab; Hyaluronidase
- Sarilumab
- Secukinumab
- Siltuximab
- Siponimod
- Sirolimus
- Streptozocin
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Tacrolimus
- Temozolomide
- Temsirolimus
- Teriflunomide
- Thiotepa
- Tildrakizumab
- Tisagenlecleucel
- Tocilizumab
- Tofacitinib
- Tositumomab
- Triamcinolone
- Ustekinumab
- Vedolizumab
- Venetoclax
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vinorelbine
