Twinrix – Hepatitis A Vaccine Inactivated Hepatitis B Vaccine Recombinant

Hepatitis A Vaccine Inactivated Hepatitis B Vaccine Recombinant Brand Name– Twinrix

What is Twinrix

Twinrix is a bivalent vaccine containing the antigenic components of hepatitis A and hepatitis B vaccines.

It is considered an inactive vaccine.

The combination is used to confer immunity in adults at risk of hepatitis A virus (HAV) and hepatitis B virus (HBV).

The antibody responses to the bivalent vaccine have been statistically equivalent to the individual vaccines.

One month after the third dose of the bivalent vaccine, the seroconversion rate against hepatitis A was 99.9%, and the seroprotection rate against hepatitis B was 98.5%.

A pediatric formulation of Twinrix, containing half the antigenic components of the adult formulation is available in other countries but is not approved in the US.

Indications

  • hepatitis A prophylaxis
  • hepatitis B prophylaxis

Side Effects

  1. abdominal pain
  2. alopecia
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. arthralgia
  8. back pain
  9. bronchospasm
  10. chills
  11. constipation
  12. diarrhea
  13. dizziness
  14. dysgeusia
  15. dyspnea
  16. ecchymosis
  17. encephalopathy
  18. erythema
  19. erythema multiforme
  20. erythema nodosum
  21. fatigue
  22. fever
  23. flushing
  24. Guillain-Barre syndrome
  25. headache
  26. hypertonia
  27. hypoesthesia
  28. injection site reaction
  29. insomnia
  30. irritability
  31. lymphadenopathy
  32. malaise
  33. migraine
  34. myalgia
  35. myelitis
  36. nausea
  37. neuritis
  38. optic neuritis
  39. paresthesias
  40. peripheral neuropathy
  41. photophobia
  42. purpura
  43. rash
  44. seizures
  45. serum sickness
  46. Stevens-Johnson syndrome
  47. syncope
  48. thrombocytopenia
  49. tinnitus
  50. urticaria
  51. vasculitis
  52. vertigo
  53. vomiting
  54. weakness

Monitoring Parameters

  • hepatitis A serology
  • hepatitis B serology

Contraindications

  • anticoagulant therapy
  • breast-feeding
  • cardiac disease
  • chemotherapy
  • children
  • coagulopathy
  • fever
  • geriatric
  • hemophilia
  • human immunodeficiency virus (HIV) infection
  • immunosuppression
  • infants
  • infection
  • intravenous administration
  • laboratory test interference
  • latex hypersensitivity
  • neomycin hypersensitivity
  • neonates
  • pregnancy
  • thrombocytopenia
  • vitamin K deficiency
  • yeast hypersensitivity

Interactions

  • Hepatitis B Immune Globulin, HBIG
  • Ocrelizumab
  • Siponimod
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