What is Trihexyphenidyl
Trihexyphenidyl is an oral synthetic, tertiary antimuscarinic. Its anticholinergic actions are similar to those of atropine. Because it is a tertiary compound, it will penetrate the CNS.
The drug is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic).
It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa.
Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.
Trihexyphenidyl was initially marketed for clinical use in 1949.
Brand Name
Artane
Indications
- drug-induced extrapyramidal symptoms
- Parkinson’s disease
- parkinsonism
- sialorrhea
For the treatment of idiopathic parkinsonism or Parkinson’s disease
Side Effects
- agitation
- anhidrosis
- anxiety
- asthenia
- blurred vision
- confusion
- constipation
- delirium
- depression
- dizziness
- drowsiness
- euphoria
- fever
- hallucinations
- headache
- heat intolerance
- hyperthermia
- ileus
- insomnia
- memory impairment
- myasthenia
- mydriasis
- nausea
- neuroleptic malignant syndrome
- ocular hypertension
- paranoia
- paresthesias
- parotitis
- psychosis
- rash
- restlessness
- sinus tachycardia
- toxic megacolon
- urinary retention
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- alcoholism
- ambient temperature increase
- anticholinergic medications
- arteriosclerosis
- autonomic neuropathy
- breast-feeding
- cardiac disease
- children
- closed-angle glaucoma
- contact lenses
- geriatric
- GI obstruction
- hepatic disease
- hypertension
- ileus
- increased intraocular pressure
- myasthenia gravis
- neurological disease
- pregnancy
- prostatic hypertrophy
- renal disease
- renal impairment
- tardive dyskinesia
- urinary tract obstruction
Trihexyphenidyl is contraindicated in patients with hypersensitivity to trihexyphenidyl or to any of the tablet or elixir ingredients.
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Aclidinium
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albuterol; Ipratropium
- Alfentanil
- Alosetron
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amantadine
- Ambenonium Chloride
- Amoxapine
- Antacids
- Anxiolytics; Sedatives; and Hypnotics
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Botulinum Toxins
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butorphanol
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Cholinergic agonists
- Cisapride
- Clemastine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Edrophonium
- Eluxadoline
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethanol
- Ezogabine
- Fentanyl
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Umeclidinium; Vilanterol
- Galantamine
- Glucagon
- Glycopyrronium
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Ipratropium
- Itraconazole
- Levocetirizine
- Levodopa
- Levorphanol
- Linaclotide
- Loperamide
- Loperamide; Simethicone
- Loxapine
- Lubiprostone
- Lurasidone
- Macimorelin
- Magnesium Hydroxide
- Maprotiline
- Meclizine
- Memantine
- Meperidine
- Meperidine; Promethazine
- Methacholine
- Methadone
- Metoclopramide
- Mirtazapine
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Neostigmine
- Nitrofurantoin
- Olanzapine
- Omeprazole; Sodium Bicarbonate
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Perphenazine
- Perphenazine; Amitriptyline
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Physostigmine
- Potassium
- Pramlintide
- Procainamide
- Prochlorperazine
- Promethazine
- Proton pump inhibitors
- Pyridostigmine
- Quetiapine
- Quinidine
- Rasagiline
- Remifentanil
- Revefenacin
- Rivastigmine
- Secretin
- Sedating H1-blockers
- Sincalide
- Sodium Bicarbonate
- Solifenacin
- Sufentanil
- Tacrine
- Tapentadol
- Tegaserod
- Thiazide diuretics
- Thioridazine
- Thiothixene
- Tiotropium
- Tiotropium; Olodaterol
- Tolterodine
- Topiramate
- Tramadol
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Triprolidine
- Trospium
- Umeclidinium
- Umeclidinium; Vilanterol
- Zonisamide
