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What is Tinidazole
Tinidazole is an oral nitroimidazole antimicrobial indicated for trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.
Although not reported with tinidazole, carcinogenicity has been seen in mice and rats treated chronically with nitroimidazole derivatives.
It is unclear if the new primary malignancy findings in lifetime rodent studies indicate a risk to patients taking a short course or single dose of tinidazole.
Therefore, limit tinidazole use to approved indications only and avoid chronic use.
Brand Name
Tindamax
Indications
- amebiasis
- bacterial vaginosis
- bacterial vaginosis prophylaxis
- Bacteroides sp.
- Entamoeba histolytica
- Gardnerella vaginalis
- Giardia duodenalis
- Giardia lamblia
- giardiasis
- Helicobacter pylori (H. pylori) eradication
- non-gonococcal urethritis (NGU)
- Prevotella sp.
- Trichomonas vaginalis
- trichomoniasis
- trichomoniasis prophylaxis
Side Effects
- angioedema
- anorexia
- arthralgia
- ataxia
- bronchospasm
- candidiasis
- coma
- confusion
- constipation
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- fever
- flatulence
- flushing
- headache
- infection
- infertility
- insomnia
- leukopenia
- malaise
- menorrhagia
- metallic taste
- myalgia
- nausea
- neutropenia
- new primary malignancy
- palpitations
- paresthesias
- pelvic pain
- peripheral neuropathy
- pharyngitis
- pruritus
- rash
- seizures
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombocytopenia
- tongue discoloration
- urine discoloration
- urticaria
- vaginal discharge
- vaginitis
- vertigo
- vomiting
- weakness
- xerostomia
Contraindications
- antimicrobial resistance
- breast-feeding
- geriatric
- hematological disease
- hepatic disease
- infertility
- laboratory test interference
- new primary malignancy
- pregnancy
- reproductive risk
- sexually transmitted disease
Interactions
- Apalutamide
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Boceprevir
- Ceritinib
- Cholestyramine
- Cimetidine
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dienogest; Estradiol valerate
- Disulfiram
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Fedratinib
- Fluorouracil, 5-FU
- Fosphenytoin
- Idelalisib
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ketoconazole
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levonorgestrel
- Lithium
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Mestranol; Norethindrone
- Mitotane
- Norethindrone
- Norgestrel
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oral Contraceptives
- Oritavancin
- Phenobarbital
- Phenytoin
- Posaconazole
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Ritonavir
- Rucaparib
- Segesterone Acetate; Ethinyl Estradiol
- Simeprevir
- Sirolimus
- Tacrolimus
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Tucatinib
- Vemurafenib
- Voriconazole
- Warfarin
- Zalcitabine, ddC
