Terconazole

What is Terconazole

Terconazole is a triazole antifungal agent available for intravaginal use. It is structurally related to imidazole-derivative antifungal agents, although imidazoles have 2 nitrogens in the azole ring while terconazole and other triazoles have 3 nitrogens in the azole ring.

Terconazole is usually fungicidal against Candida albicans.

Although antifungal activity has been demonstrated against other fungi, it is indicated only for the treatment of vulvovaginal candidiasis. Terconazole was approved by the FDA in 1987.

Brand Names

  • Terazol 3
  • Terazol 7
  • Zazole

Indications

  • Candida albicans
  • Candida sp.
  • vulvovaginal candidiasis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • contraceptive devices
  • infants
  • menstruation
  • neonates
  • ocular exposure
  • ophthalmic administration
  • pregnancy

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. arthralgia
  4. asthenia
  5. bronchospasm
  6. chills
  7. dizziness
  8. dysmenorrhea
  9. fever
  10. headache
  11. malaise
  12. myalgia
  13. nausea
  14. photosensitivity
  15. pruritus
  16. rash
  17. teratogenesis
  18. toxic epidermal necrolysis
  19. urticaria
  20. vaginal irritation
  21. vaginal pain
  22. vomiting

Interactions

There are no drug interactions associated with Terconazole products.

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