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What is Teduglutide
Teduglutide is a recombinant glucagon-like peptide-2 (GLP-2) analog.
The drug is used to treat pediatric and adult patients with intestinal failure secondary to short bowel syndrome (SBS) who are dependent on parenteral nutrition.
Brand Name
Gattex
Indications
- short bowel syndrome
For the treatment of short bowel syndrome in patients who are dependent on parenteral support
Side Effects
- abdominal pain
- antibody formation
- blepharedema
- cholangitis
- cholecystitis
- cholelithiasis
- cholestasis
- cough
- dyspnea
- edema
- erythema
- flatulence
- fluid retention
- flushing
- GI obstruction
- heart failure
- infection
- influenza
- injection site reaction
- maculopapular rash
- nausea
- new primary malignancy
- pancreatitis
- peripheral edema
- pruritus
- rash
- urticaria
- vomiting
Monitoring Parameters
- colonoscopy
- serum alkaline phosphatase
- serum amylase
- serum bilirubin
- serum creatinine/BUN
- serum electrolytes
- serum lipase
- serum osmolality
- weight
Contraindications
- biliary tract disease
- breast-feeding
- cardiac disease
- electrolyte imbalance
- gallbladder disease
- GI obstruction
- heart failure
- neoplastic disease
- new primary malignancy
- pancreatitis
- pregnancy
- renal failure
- renal impairment
Interactions
- Alprazolam
- Amitriptyline; Chlordiazepoxide
- Benzodiazepines
- Carbamazepine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Clonazepam
- Clorazepate
- Cyclosporine
- Dextromethorphan; Quinidine
- Diazepam
- Digoxin
- Disopyramide
- Estazolam
- Ethosuximide
- Flecainide
- Flurazepam
- Lithium
- Lorazepam
- Midazolam
- Oxazepam
- Phenytoin
- Procainamide
- Quazepam
- Quinidine
- Sirolimus
- Tacrolimus
- Temazepam
- Theophylline, Aminophylline
- Thyroid hormones
- Triazolam
- Valproic Acid, Divalproex Sodium
- Warfarin
