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What is Tasimelteon
Tasimelteon, a melatonin receptor agonist, is used for the treatment of non-24-hour sleep-wake disorder (non-24) in patients that are completely blind and have difficulties falling asleep, staying asleep, or who feel drowsy upon wakening.
Non-24 is a chronic circadian rhythm disorder that occurs in blind patients because they cannot synchronize their circadian rhythms to a light-dark cycle. Tasmelteon was FDA-approved in January 2014.
Brand Name
HETLIOZ
Indications
- non-24-hour sleep-wake disorder
Side Effects
- abnormal dreams
- drowsiness
- elevated hepatic enzymes
- headache
- infection
- nightmares
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- activities requiring coordination and concentration
- alcoholism
- breast-feeding
- children
- driving or operating machinery
- endocrine disease
- ethanol ingestion
- ethanol intoxication
- geriatric
- hepatic disease
- hyperprolactinemia
- infants
- infertility
- pregnancy
- tobacco smoking
Interactions
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alprazolam
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Beta-blockers
- Betaxolol
- Bexarotene
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Butabarbital
- Caffeine
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloramphenicol
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clemastine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Conivaptan
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dorzolamide; Timolol
- Doxylamine
- Doxylamine; Pyridoxine
- Dronedarone
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esketamine
- Eslicarbazepine
- Esmolol
- Ethanol
- Ethotoin
- Etravirine
- Fentanyl
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Gabapentin
- Givosiran
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Labetalol
- Lasmiditan
- Lemborexant
- Letermovir
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levorphanol
- Lofexidine
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Methadone
- Methohexital
- Metoprolol
- Mexiletine
- Mitotane
- Modafinil
- Morphine
- Morphine; Naltrexone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nevirapine
- Nilotinib
- Obeticholic Acid
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oxycodone
- Oxymorphone
- Penbutolol
- Pentobarbital
- Phenobarbital
- Phenytoin
- Pindolol
- Posaconazole
- Pregabalin
- Primidone
- Propranolol
- Ramelteon
- Remifentanil
- Rifabutin
- Rifampin
- Ritonavir
- Safinamide
- Saquinavir
- Secobarbital
- Sedating H1-blockers
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Suvorexant
- Tapentadol
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Thiabendazole
- Thiopental
- Timolol
- Tipranavir
- tobacco
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triprolidine
- Vemurafenib
- Verapamil
- Voriconazole
- Zileuton
